Simulated microgravity-induced aortic remodeling
نویسندگان
چکیده
منابع مشابه
Simulated microgravity-induced aortic remodeling.
We have previously shown that microgravity and simulated microgravity induce an increase in human and rat aortic stiffness. We attempted to elucidate the mechanism(s) responsible for this increase in stiffness. We hypothesize that an alteration in vessel wall collagen or elastin content or in extracellular matrix (ECM) cross-linking either individually or in a combination is responsible for the...
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Human cardiovascular system has adapted to Earth's gravity of 1G. The microgravity during space flight can induce cardiac remodeling and decline of cardiac function. At present, the mechanism of cardiac remodeling induced by microgravity remains to be disclosed. Casein kinase-2 interacting protein-1 (CKIP-1) is an important inhibitor of pressure-overload induced cardiac remodeling by decreasing...
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ژورنال
عنوان ژورنال: Journal of Applied Physiology
سال: 2009
ISSN: 8750-7587,1522-1601
DOI: 10.1152/japplphysiol.90777.2008